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Please use this identifier to cite or link to this item: http://hdl.handle.net/10271/3202

Title: BMP signaling-related proteins are differentially expressed in the adult cerebellum
Other Titles: BMPシグナル関連タンパク質は成体小脳において多様性を持って発現している
Authors: Kesavamoorthy, Gandhervin
Keywords: BMP
BMP receptor
chordin
noggin
immunohistochemistry
Issue Date: 2016
Publisher: 日本脳科学会
Abstract: We investigated the distributions of BMP ligands (BMP2, BMP4, BMP5), BMP receptors (BMPR) (BMPRIA, BMPR IB, BMPR II ), BMP antagonists (chordin and noggin) in the adult rat cerebellum. They are differentially expressed throughout the cerebellum. Interestingly, they are more abundantly expressed in the molecular cell layer, where neuronal plastic phenomena, such as long-term depression (LTD) and rebound potentiation (RP) are observed, than in the granule cell layer. In addition, neurons in the cerebellar nuclei also express all of them. We also found differential usages of BMPRIA and BMPRIB in the cerebellum. For example, in the molecular layer, BMPRIA is mainly expressed in the processes of Bergmann glia, while BMPRIB is mainly detected in the dendrites of Purkinje cells. In addition, BMPRIB is expressed in both cell bodies and dendrites of Purkinje cells, while BMPRIA is mainly expressed in cell bodies of Purkinje cells, showing that BMPRIA and BMPRIB are differentially targeted in a Purkinje cell. These data strongly indicate that differential BMP signaling should be needed to keep the proper function of the cerebellum in the adult rat cerebellum.
Description: 浜松医科大学学位論文 医博第736号(平成28年9月16日)
URI: http://hdl.handle.net/10271/3202
DOI: info:doi/10.20821/jbs.46.0_70
Academic Degrees and number: 13802甲第736号
Degree-granting date: 2016-09-16
Degree name: 博士(医学)
Degree-granting institutions: 浜松医科大学
Appears in Collections:2010 博士(論文)

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