DSpace About DSpace Software 日本語
 

HamaMed-Repository >
20 学位論文 >
2010 博士(論文) >

Please use this identifier to cite or link to this item: http://hdl.handle.net/10271/3147

Title: DHA-PC and PSD-95 decrease after loss of synaptophysin and before neuronal loss in patients with Alzheimer’s disease
Other Titles: アルツハイマー病患者ではシナプトフィジンの減少後にDHA-PCとPSD-95が減少し、神経細胞が脱落する
Authors: Yuki, Dai
由木, 大
Issue Date: 20-Nov-2014
Publisher: Nature Publishing Group
Abstract: Alzheimer’s disease (AD) is a progressive neurodegenerative disease that is characterized by senile plaques, neurofibrillary tangles, synaptic disruption, and neuronal loss. Several studies have demonstrated decreases of docosahexaenoic acid-containing phosphatidylcholines (DHA-PCs) in the AD brain. In this study, we used matrix-assisted laser desorption/ionization imaging mass spectrometry in postmortem AD brain to show that PC molecular species containing stearate and DHA, namely PC(18:0/22:6), was selectively depleted in the gray matter of patients with AD. Moreover, in the brain regions with marked amyloid b (Ab) deposition, the magnitude of the PC(18:0/22:6) reduction significantly correlated with disease duration. Furthermore, at the molecular level, this depletion was associated with reduced levels of the postsynaptic protein PSD-95 but not the presynaptic protein synaptophysin. Interestingly, this reduction in PC(18:0/22:6) levels did not correlate with the degrees of Ab deposition and neuronal loss in AD. The analysis of the correlations of key factors and disease duration showed that their effects on the disease time course were arranged in order as Ab deposition, presynaptic disruption, postsynaptic disruption coupled with PC(18:0/22:6) reduction, and neuronal loss.
Description: 浜松医科大学学位論文 医博論第526号(平成28年3月9日)
URI: http://hdl.handle.net/10271/3147
DOI: info:doi/10.1038/srep07130
PubMed ID: info:pmid/25410733
Academic Degrees and number: 13802乙第526号
Degree-granting date: 2016-03-09
Degree name: 博士(医学)
Degree-granting institutions: 浜松医科大学
Appears in Collections:2010 博士(論文)

Files in This Item:

File Description SizeFormat
DT_ron526ronbun.pdf1.27 MBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

 

Valid XHTML 1.0! DSpace Software Copyright © 2002-2010  Duraspace - Feedback