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Please use this identifier to cite or link to this item: http://hdl.handle.net/10271/3146

Title: Foxc2 in pharyngeal arch mesenchyme is important for aortic arch artery remodelling and ventricular septum formation
Other Titles: 咽頭弓の間葉で発現するFoxc2は大動脈弓の動脈再構築と心室中隔形成に重要である
Authors: Uddin, Mohammad Khaja Mafij
Issue Date: 2015
Publisher: Biomedical Research Press
Abstract: The forkhead box C2 (Foxc2) protein is a member of the forkhead/winged helix transcription factor family and plays an essential role in cardiovascular development. Previous studies showed that Foxc2 null mouse embryos die during midgestation or just after birth with severe cardiovascular defects, including interruption, coarctation of the aortic arch and ventricular septal defects. These are also seen in human congenital heart disease. However, the tissue specific role of Foxc2 in aortic arch remodelling is not yet fully understood. Here we show that Foxc2 is expressed in a restricted pattern in several cell populations, including the mesenchyme and endothelium of pharyngeal arch arteries, which are important for cardiovascular development. In this study, we use a conditional knockout approach to examine the tissue specific role of Foxc2 in aortic arch remodelling. We demonstrate that mouse embryos lacking Foxc2 in Nkx2.5-expressing mesenchyme and endothelium of pharyngeal arch arteries display aortic arch interruption type B and ventricular septal defects. In contrast, conditional deletion of Foxc2 in Tie2-expressing endothelial cells does not result in aortic arch or ventricular septal defects, but does result in embryonic lethality due to peripheral oedema. Our data therefore provide for a detailed understanding of the role of mesenchymal Foxc2 in aortic arch remodelling and in the development of ventricular septum.
Description: 浜松医科大学学位論文 医博第725号(平成28年3月14日)
URI: http://hdl.handle.net/10271/3146
DOI: info:doi/10.2220/biomedres.36.235
PubMed ID: info:pmid/26299482
Academic Degrees and number: 13802甲第725号
Degree-granting date: 2016-03-14
Degree name: 博士(医学)
Degree-granting institutions: 浜松医科大学
Appears in Collections:2010 博士(論文)

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