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Please use this identifier to cite or link to this item: http://hdl.handle.net/10271/2909

Title: Simultaneous determination of coinage metals, copper, silver and gold in tissues using electrospray ionization tandem mass spectrometry
Authors: Minakata, Kayoko
Yamagishi, Itaru
Nozawa, Hideki
Gonmori, Kunio
Hasegawa, Koutaro
Suzuki, Masako
Horio, Fumihiko
Watanabe, Kanako
Suzuki, Osamu
Keywords: Copper
Electrospray ionization
Tandem mass spectrometry
Issue Date: Jul-2012
Publisher: Springer Japan
Abstract: A rapid and sensitive mass spectrometric method was developed for the simultaneous determination of coinage metals such as copper (Cu), silver (Ag) and gold (Au). The metals in a wet ashed tissue solution were complexed with diethyldithiocarbamate (DDC; C4H10NCS2) and were extracted together with isoamyl alcohol. After the acidification of the extract with oxalic acid, metals were quantified using their product ions, Cu(DDCH)+, Ag(DDCH) + and Au(DDCH)+ that derived from the precursor ions Cu(DDC)2+, Ag(DDC)2 + and Au(DDC)2+, respectively, by electrospray ionization tandem mass spectrometry. The limits of detection were 0.6, 0.3 and 1 μgl–1 for Cu, Ag and Au and the quantification ranges were 2 – 100, 1 – 100 and 3 – 100 μgl–1 for Cu, Ag and Au, respectively. Cu levels in spontaneously hypertensive osteogenic disorder rats at 6 weeks old and at 30 weeks old were found to be 1.8 times and 5.1 times those of the normotensive osteogenic disorder rats, respectively, when using wet-ashed kidney solutions diluted to 1,000 fold.
URI: http://hdl.handle.net/10271/2909
DOI: info:doi/10.1007/s11419-012-0134-9
Appears in Collections:1010 雑誌掲載論文

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