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Please use this identifier to cite or link to this item: http://hdl.handle.net/10271/2532

Title: 創薬のための新しい病態モデル
Authors: 中島, 光好
梅村, 和夫
滝口, 祥令
Issue Date: 2007
Publisher: 日本臨床薬理学会
Citation: 日本薬理学雑誌 Vol.102 , No.3(1993)pp.191-199
Abstract: Development of novel drugs relies on research to discover new drugs. Testing and evaluating new drugs on human subjects are usually impossible because of ethical concerns. Therefore, for drug discovery research, it is essential to establish animal models of human diseases. Numerous animal models have been developed and used in drug discovery and evaluation studies. Such animal models have had important roles in developing new drugs as well as understanding the etiologies of diseases. In the field of cardiovascular drugs, several interesting animal models are currently in use. These include, transgenic mice carrying both human renin and human angiotensinogen genes, Watanabe's heritable hyperlipidemic rabbits, rats with pulmonary hypertension induced by monocrotaline, myocardial infarction model, cardial hypertrophy model and photochemical thrombosis models. It is envisaged that for drug discovery and development, the search for more physiological animal models will continue in the future.
Description: rights: 日本臨床薬理学会
rights: 本文データは学協会の許諾に基づきJournal Archiveから複製したものである
URI: http://hdl.handle.net/10271/2532
ISSN: 1347-8397(ONLINE)
URI: http://dx.doi.org/10.1254/fpj.102.191
DOI: info:doi/10.1254/fpj.102.191
Appears in Collections:1010 雑誌掲載論文

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